This software will find common hits between a high-throughput reference database* (A) and a user-defined high-throughput dataset (B):
| Taxol apoptosis protectors (Díaz-Martínez, 2014, EMBO J; PMID: 25024437) |
| Taxol apoptosis sensitizers (Díaz-Martínez, 2014, EMBO J; PMID: 25024437) |
| Genes mediating TNF induced NFKB activity (Nickles et al, 2012, Mol Cell Biol; PMID: 22733992) |
| Genes inhibiting TNF induced NFKB activity (Nickles et al, 2012, Mol Cell Biol; PMID: 22733992) |
| 897 genes expressed exclusively in Microglia (>20 FPKM) (http://web.stanford.edu/group/barres_lab/brain_rnaseq.html) |
| NFKB targets (http://www.bu.edu/nf-kb/gene-resources/target-genes/) |
| Autophagy flux inhibitors (Lipinski et al, 2010, Dev Cell; PMID: 20627085) |
| Candidates for positive regulators of normal growth (DESeq) (Beronja et al., 2013, Nature; PMID: 23945586) |
| Candidates for negative regulators of normal growth (DESeq) (Beronja et al., 2013, Nature; PMID: 23945586) |
| Candidates for positive regulators of oncogenic growth (DESeq) (Beronja et al., 2013, Nature; PMID: 23945586) |
| Candidates for negative regulators of oncogenic growth (DESeq) (Beronja et al., 2013, Nature; PMID: 23945586) |
| Knockdown causes sensitivity to tamoxifen (Mendes-Pereira et al., 2011, PNAS; PMID: 21482774) |
| Knockdown causes resistance to tamoxifen (Mendes-Pereira et al., 2011, PNAS; PMID: 21482774) |
| CRISPR screen for essential genes in the human genome - KBM7 cells, p<0.05 (Wang et al., 2015, Science; PMID: 26472758) |
| CRISPR screen for essential genes in the human genome - K562 cells, p<0.05 (Wang et al., 2015, Science; PMID: 26472758) |
| CRISPR screen for essential genes in the human genome - Jiyoye cells, p<0.05 (Wang et al., 2015, Science; PMID: 26472758) |
| CRISPR screen for essential genes in the human genome - Raji cells, p<0.05 (Wang et al., 2015, Science; PMID: 26472758) |
| Ca2+ influx mediators (Genome-wide RNAi screen in Drosophila cells) (Vig et al., 2006, Science; PMID: 16645049) |
| Modifiers of the Circadian Clock in Human Cells (Genome-wide RNAi screen; Zhang et al., 2009, Cell; PMID: 19765810) |
| Synthetic Lethal Interactions with the Ras Oncogene (Genome-wide RNAi screen; Luo et al., 2009, Cell; PMID: 19490893) |
| Mediators of Genome Stability (Genome-wide siRNA Screen; Significant gamma-H2AX Values; p<0.05) (Paulsen et al., 2009, Mol Cell; PMID: 19647519) |
| Camptothecin sensitivity (Genome-wide RNAi screen; O'Connell et al., 2010, Mol Cell; PMID: 21055985) |
| Modulators of ciliogenesis (Genome-wide RNAi screen; Kim et al., 2016, Biochimica et Biophysica Acta; PMID: 27033521) |
| Regulators of centriole biogenesis (Genome-wide RNAi screen; Balestra et al., 2010, Dev Cell; PMID: 23769972) |
| Regulators of beta-catenin-dependent WNT Signaling (Genome-wide RNAi screen; Madan et al., 2010, PNAS; PMID: 27162353) |
| Genes Essential for West-Nile-Virus-Induced Cell Death (Genome-wide RNAi screen; Ma et al., 2015, Cell Reports; PMID: 26190106) |
| Protector Hits from Taxol-Induced Mitotic Arrest and Apoptosis (Genome-wide RNAi screen; Díaz-Martínez et al., 2014, EMBO J; PMID: 25024437) |
| Sensitizer Hits from Taxol-Induced Mitotic Arrest and Apoptosis (Genome-wide RNAi screen; Díaz-Martínez et al., 2014, EMBO J; PMID: 25024437) |
| Modulators of Ca2+/NFAT signalling (Genome-wide RNAi screen; Sharma et al., 2013, Nature; PMID: 23792561) |
| Host Factors Necessary for Growth of the Parasite Toxoplasma gondii (Genome-wide RNAi screen; Moser et al., 2013, PLoS ONE; PMID: 23840822) |
| Host Factors Necessary for human papillomavirus infection (Genome-wide RNAi screen; Lipovsky et al., 2013, PNAS; PMID: 23569269) |
| Host Factors Necessary for poxvirus morphogenesis (Table S2 - Genome-wide RNAi screen; Sivan et al., 2013, PNAS; PMID: 23401514) |
| Host factors affecting C. burnetii growth phenotypes (Genome-wide RNAi screen; McDonough et al., 2013, MBio; PMID: 23362322) |
| Regulators of clathrin-coated vesicle formation (Kozik et al., 2013, Nat Cell Biol, PMID: 23263279) |
| Host Proteins Promoting Alphavirus Entry (Genome-wide RNAi screen; Ooi et al., 2013, PLoS Pathog, PMID: 24367265) |
| Host Proteins Inhibiting Alphavirus Entry (Genome-wide RNAi screen; Ooi et al., 2013, PLoS Pathog, PMID: 24367265) |
| SOD1 Regulators (Genome-wide RNAi screen; Somalinga et al., 2012, PLoS One, PMID: 22563406) |
| Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib (Genome-wide RNAi screen; Chen et al., 2010, Cancer Res, PMID: 20460535) |
| Regulators of human papillomavirus oncogene expression (Genome-wide RNAi screen; Smith et al., 2010, PNAS, PMID: 20133580) |
| Enhancers of a kinesin-5 inhibitor K5I (Genome-wide RNAi screen; Tsui et al., 2009, PLoS One, PMID: 19802393) |
| Suppressors of a kinesin-5 inhibitor K5I (Genome-wide RNAi screen; Tsui et al., 2009, PLoS One, PMID: 19802393) |
| Regulators of caspase activation (Genome-wide RNAi screen; Yi et al., 2007, J Cell Biol, PMID: 17998402) |
| Genes essential for cell division (Genome-wide RNAi screen; Kittler et al., 2004, Nature, PMID: 15616564) |
| Positive modulators of p62/Sqstm1/canonical macroautophagy (Genome-wide CRISPR screen; DeJesus et al., 2016, eLIFE, PMID: 27351204) |
| Negative modulators of p62/Sqstm1/canonical macroautophagy (Genome-wide CRISPR screen; DeJesus et al., 2016, eLIFE, PMID: 27351204) |
| Host factors required for diphteria toxin-mediated toxicity (Genome-wide RNAi screen; Virreira Winter et al., 2016, Sci Rep, PMID: 27351204) |
| Host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity (Genome-wide RNAi screen; Virreira Winter et al., 2016, Sci Rep, PMID: 27351204) |
| Nigericin-resistant knockouts (1.5-fold sgRNA ratio) (Genome-wide CRISPR screen; Schmid-Burgk et al., 2016, J Biol Chem, PMID: 26553871) |
| Protein-coding genes affecting myeloid leukemia cell growth (MV4-11) (Genome-wide CRISPR screen; Wallace et al., 2016, PLoS One, PMID: 27081855) |
| miRNAs affecting myeloid leukemia cell growth (MV4-11) (Genome-wide CRISPR screen; Wallace et al., 2016, PLoS One, PMID: 27081855) |
| Novel modulators of HLA-I ERAD (Genome-wide RNAi screen; van de Weijer et al., 2014, Nat Commun, PMID: 24807418) |
| Crapome (Mellacheruvu et al., 2013, Nat Methods; PMID: 23921808) |
| Peripheral membrane proteins (Nastou et al, 2014, Biomed Res Int; PMID: 25057483) |
| Proteome of mouse photoreceptor sensory cilium (Liu et al, 2007, Mol Cell Proteomics; PMID: 17494944) |
| mTORC1 targets - Rapamycin >2-fold (Yu, 2011, Science; PMID: 21659605) |
| mTOR targets - Ku-0063794 >2-fold (Yu, 2011, Science; PMID: 21659605) |
| Complex-I TNF-5min/ctrl interactors (>1.5-fold) (Wagner, 2016, EMBO J, PMID: 27307491) |
| Complex-I TNF-15min/ctrl interactors (>1.5-fold) (Wagner, 2016, EMBO J, PMID: 27307491) |
| Complex-I TNF-5min/ctrl phosphorylated (>1.5-fold) (Wagner, 2016, EMBO J, PMID: 27307491) |
| Complex-I TNF-15min/ctrl phosphorylated (>1.5-fold) (Wagner, 2016, EMBO J, PMID: 27307491) |
| Complex-I TNF-5min/ctrl ubiquitinated (>1.5-fold) (Wagner, 2016, EMBO J, PMID: 27307491) |
| Complex-I TNF-15min/ctrl ubiquitinated (>1.5-fold) (Wagner, 2016, EMBO J, PMID: 27307491) |
| RIP3 WT/KO >1.5-fold (TNF-MEF) Wu et al 2012 MCP (PMID: 22942356) |
| RIP3 WT/KO >1.5-fold (LPS-macrophage) Wu et al 2012 MCP (PMID: 22942356) |
| Global Identification of Modular Cullin-Ring Ligase Substrates (Emanuele et al., 2011, Cell; PMID: 21963094) |
| AMPK substrates (Schaffer BE et al., 2015, Cell Metabolism; PMID: 26456332 ) |
| Phosphorylated exclusively in G1-phase (Dephoure et al., 2008, PNAS; PMID: 18669648) |
| Phosphorylated exclusively in M-phase (Dephoure et al., 2008, PNAS; PMID: 18669648) |
| Phosphorylated in both G1-phase and in M-phase (Dephoure et al., 2008, PNAS; PMID: 18669648) |
| Ubiquitination in the DNA Damage Response (UV, >1.5-fold) (Elia et al., 2015, Mol Cell; PMID: 26051181) |
| Ubiquitination in the DNA Damage Response (IR, >1.5-fold) (Elia et al., 2015, Mol Cell; PMID: 26051181) |
| Phosphorylation in the DNA Damage Response (UV, >1.5-fold) (Elia et al., 2015, Mol Cell; PMID: 26051181) |
| Phosphorylation in the DNA Damage Response (IR, >1.5-fold) (Elia et al., 2015, Mol Cell; PMID: 26051181) |
| Proteins differentially phosphorylated upon CDKN3 knockdown (PhosphoScan proteomic platform (Cell Signaling Technology); Nalepa et al., 2013, J Cell Biol; PMID: 23775190) |
| The CRAPome - a contaminant repository for affinity purification-mass spectrometry data (Mellacheruvu et al., 2013, Nat Methods; PMID: 23921808) |
